Authors: Ihab Atallah Clément Milet JeanLuc Coll Emile Reyt Christian Adrien Righini Amandine Hurbin
Publish Date: 2014/08/13
Volume: 272, Issue: 10, Pages: 2593-2600
Abstract
Complete resection of head and neck cancers with negative surgical margins improves the prognosis of the disease and decreases the recurrence rate Nearinfrared fluorescenceguided surgery of head and neck cancer is a rapidly evolving field that represents an invaluable tool for tumor detection and resection Here we present a literature review of the principles of nearinfrared fluorescence imaging and its use in head and neck cancer surgery We discuss important studies in both animal models and humans that have been carried out up to this point We also outline the important fluorescent molecules and devices used in head and neck fluorescence imagingguided surgery Although nearinfrared fluorescenceguided surgery for head and neck cancers showed efficacy in animal models its use in humans is limited by the small number of fluorescent probes that are approved for clinical use However it is considered as a novel surgical aid that helps delineate tumor margins preoperatively and could spare patients from the added morbidity that is associated with additional surgery or chemoradiation In addition it is a useful tool to detect sentinel lymph nodes as well as metastatic lymph nodes
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