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Title of Journal: Eur Arch Otorhinolaryngol

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Abbravation: European Archives of Oto-Rhino-Laryngology

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Springer-Verlag

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DOI

10.1002/cite.3306909114

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ISSN

1434-4726

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Functional variants of MIF INFG and TFNA genes ar

Authors: Irene Gázquez Antonia Moreno Teresa Requena Jeff Ohmen Sofia SantosPerez Ismael Aran Andres SotoVarela Herminio PérezGarrigues Alicia LópezNevot Angel Batuecas Rick A Friedman Miguel A LópezNevot Jose A LópezEscamez
Publish Date: 2012/11/21
Volume: 270, Issue: 4, Pages: 1521-1529
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Abstract

Variability in acute immune response genes could determine susceptibility or prognosis for Ménière′s disease MD The cytokines tumor necrosis factor α TNFα macrophage migration inhibitory factor MIF and interferon γ INFγ are proinflammatory cytokines of the innate immune response These cytokines mediate inflammation and have been previously associated with the inflammatory process in several autoimmune diseases We investigated the association between functional allelic variants of MIF rs35688089 IFNG rs2234688 and TNFA rs1800629 in patients with MD In addition to testing these variants for an association with disease we also tested for an association with clinical aspects of disease progression such as persistence of vertigo and the sensorineural hearing loss A total of 580 patients with diagnosis of definite MD according to the diagnostic scale of the American Academy of OtolaryngologyHead and Neck Surgery and 552 healthy controls were included DNA samples from a set of 291 American patients were used to confirm the results obtained in the MIF gene in our Spanish cohort Although we found a significant association with the allele containing five repeats of CATT within the MIF gene in patients with MD in the Spanish cohort corrected p = 0008 OR = 069 95  CI 054–088 this finding could not be replicated in the American set Moreover no genetic associations for variants in either the TNFA or IFNG genes and MD were found These results support the conclusion that functional variants of MIF INFG and TFNA genes are not associated with disease susceptibility or hearing loss progression in patients with MDThis work was funded by Research Grants FIS PI09/00920 from Instituto de Salud Carlos III and BIO103SA/51/11 from Health Department of the Castilla y Leon Regional Government by FEDER Funds from the EU JALE was partially supported by DP00412011 Grant from Health Department of Andalusian Regional Government

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