Authors: Raşit Cevizci Mehmet Düzlü Yasemin Dündar Ningur Noyanalpan Nedim Sultan Hakan Tutar Yıldırım A Bayazıt
Publish Date: 2014/02/26
Volume: 272, Issue: 6, Pages: 1389-1393
Abstract
The purpose of the study is to assess the effect of a novel quorum sensing inhibitor QSI coded as ‘yd 47’ against otitis media and biofilm formation on Cochlear implants CIs Small pieces cut from cochlear implant were implanted under the skin in the retroauricular area on both sides of four guinea pigs The implant pieces in the study and control sides were implanted in Streptococcus pneumoniae strain solution and saline respectively The right and left middle ears were also instilled with a solution containing pneumococci and saline respectively The animals were only given an intraperitoneal ‘yd 47’ twice daily for three months to be assessed later with electron microscopy Clinical examination with palpation inspection and otoscopy did not reveal any sign of implant infection or otitis media In the study and control implant materials soft tissues around the implant and tympanic membranes there was no biofilm formation by pneumococci Contamination by various cells and some rodshaped bacteria not diplococcic were seen in some of the materials In conclusion the novel QSI seems promising in the prevention of otitis media and biofilm formation on CIs by pneumococci
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