Authors: Panithaya Chareonthaitawee Klaus Schaefers Christopher S Baker Federico Turkheimer Lars Stegger Nicholas R Banner Magdi Yacoub Robert S Bonser Patricia Iozzo Paolo G Camici Ornella Rimoldi
Publish Date: 2001/12/14
Volume: 29, Issue: 2, Pages: 203-215
Abstract
Along with hibernating myocardium infarct size is a critical term in the progression of left ventricular remodelling and congestive heart failure Both infarcted and hibernating myocardium determine changes in remote nonischaemic tissue This study was designed to test the accuracy of a new technique to quantify infarct size using positron emission tomography PET with 18F2fluoro2deoxyDglucose FDG Studies were carried out in a nine pigs with acute myocardial infarction two shamoperated produced by a 90min occlusion of the circumflex coronary artery followed by a 4h reperfusion and b humans six patients with ischaemic cardiomyopathy awaiting cardiac transplantation and five normal volunteers In both animals and patients myocardial FDG uptake was measured by PET during hyperinsulinaemiceuglycaemic clamp Infarct size was quantified by an absolute threshold of tracer uptake obtained from the parametric voxelbyvoxel image of the metabolic rate of FDG PET infarct size estimates were compared with independent ex vivo planimetric measurements of the explanted swine and patient hearts at transplantation after staining with triphenyltetrazolium chloride There was good agreement between the planimetric and PET infarct size estimates both in pigs n=9 r=096 y=094x +064 SEE=010 P00001 and in humans n=11 r=094 y=072x +293 SEE=009 P00001 This study demonstrates the feasibility and accuracy of this PET method in estimating infarct size both in a model of reperfused acute myocardial infarction and in chronic ischaemic cardiomyopathy although larger studies are needed to confirm these findings
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