Authors: Jingjie Shang Xueying Ling Linyue Zhang Yongjin Tang Zeyu Xiao Yong Cheng Bin Guo Jian Gong Li Huang Hao Xu
Publish Date: 2016/05/28
Volume: 43, Issue: 11, Pages: 1945-1953
Abstract
To compare the Response Evaluation Criteria in Solid Tumors RECIST 11 the European Organization for Research and Treatment of Cancer EORTC criteria and the Positron Emission Tomography Response Criteria in Solid Tumors PERCIST 10 using PET volume computerassisted reading PET VCAR for response evaluation in patients with advanced nonsmallcell lung cancer NSCLC treated with chemotherapyA total of 35 patients with NSCLC were included in this prospective study All patients received standard chemotherapy and underwent 18FFDG PET/CT scans before and after treatment With the assistance of PET VCAR the chemotherapeutic responses were evaluated according to the RECIST 11 EORTC criteria and PERCIST 10 Concordance among these protocols was assessed using Cohen’s κ coefficient and Wilcoxon’s signedranks test Progressionfree survival PFS was calculated using the KaplanMeier testRECIST 11 and EORTC response classifications were discordant in 20 patients 571 κ = 0194 P 005 and RECIST 11 and PERCIST 10 classifications were discordant in 22 patients 629 κ = 0139 P 005 EORTC and PERCIST 10 classifications were discordant in only 4 patients 114 resulting in better concordance κ = 0804 P 005 Patients with a partial remission according to RECIST 11 had significantly longer PFS P 0001 than patients with progressive disease but not significantly longer than patients with stable disease P = 0855 According to both the EORTC criteria and PERCIST 10 patients with a partial metabolic response had a significantly longer PFS than those with stable metabolic disease and those with progressive metabolic disease P = 0020 and P 0001 respectively for EORTC both P 0001 for PERCIST 10EORTC criteria and PERCIST 10 are more sensitive and accurate than RECIST 11 for the detection of an early therapeutic response to chemotherapy in patients with NSCLC Although EORTC criteria and PERCIST 10 showed similar results PERCIST 10 is preferred because detailed and unambiguous definitions are given We also found that response evaluations with PERCIST 10 using a single lesion and multiple lesions gave similar response classificationsAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the principles of the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards This article does not describe any studies with animals performed by any of the authors
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