Authors: Brittany Z Dashevsky Debra A Goldman Molly Parsons Mithat Gönen Adriana D Corben Maxine S Jochelson Clifford A Hudis Monica Morrow Gary A Ulaner
Publish Date: 2015/05/14
Volume: 42, Issue: 11, Pages: 1666-1673
Abstract
This retrospective study was performed under IRB waiver Our Hospital Information System was screened for breast cancer patients who presented with osseous metastases who underwent FDG PET/CT prior to systemic therapy or radiotherapy from 2009 to 2012 Patients with invasive ductal carcinoma IDC invasive lobular carcinoma ILC or mixed ductal/lobular MDL histology were included Patients with a history of other malignancies were excluded PET/CT was evaluated blinded to histology to classify osseous metastases on a perpatient basis as sclerotic lytic mixed lytic/sclerotic or occult on CT and to record SUVmax for osseous metastases on PETFollowing screening 95 patients who met the inclusion criteria 74 IDC 13 ILC and 8 MDL were included ILC osseous metastases were more commonly sclerotic and demonstrated lower SUVmax than IDC metastases In all IDC and MDL patients with osseous metastases at least one was FDGavid For ILC all patients with lytic or mixed osseous metastases demonstrated at least one FDGavid metastasis however in only three of seven patients were sclerotic osseous metastases apparent on FDG PETThe histologic subtype of breast cancer affects the appearance of untreated osseous metastases on FDG PET/CT In particular nonFDGavid sclerotic osseous metastases were more common in patients with ILC than in patients with IDC Breast cancer histology should be considered when interpreting nonFDGavid sclerotic osseous lesions on PET/CT which may be more suspicious for metastases rather than benign lesions in patients with ILCAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the principles of the1964 Declaration of Helsinki and its later amendments or comparable ethical standards
Keywords: