Authors: Yuka Yamamoto Yoshihiro Nishiyama Toshihide Monden Yasuhiro Sasakawa Motoomi Ohkawa Masashi Gotoh Kotaro Kameyama Reiji Haba
Publish Date: 2005/10/12
Volume: 33, Issue: 2, Pages: 140-147
Abstract
FDGPET studies were performed before and after completion of chemoradiotherapy prior to surgery in 26 patients with NSCLC FDGPET imaging was performed at 1 h early and 2 h delayed after injection Semiquantitative analysis was performed using the standardised uptake value SUV at the primary tumour Percent change was calculated according to the following equation left textSUV textafter textSUV textbefore right times 100 mathordleft/ vphantom 100 textSUV textbefore right kernnulldelimiterspace textSUV textbefore Based on histopathological analysis of the specimens obtained at surgery patients were classified as pathological responders or pathological nonresponders The clinical nodal stage on the postchemoradiotherapy PET scan was visually determined and compared with the final pathological stageEighteen patients were found to be pathological responders and eight to be pathological nonresponders SUVafter values from both early and delayed images in pathological responders were significantly lower than those in pathological nonresponders The percent change values from early and delayed images in the pathological responders were significantly higher than those in the pathological nonresponders The postchemoradiotherapy PET scan accurately predicted nodal stage in 22 of 26 patients
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