Authors: C Weytjens B Cosyns G Van Camp C Daniels K Spincemaille A Dupont P R Franken
Publish Date: 2005/08/17
Volume: 32, Issue: 11, Pages: 1317-1323
Abstract
In subjects without underlying cardiac disease dobutamine is known to enhance systolic LV function and LV relaxation As endsystolic ES and enddiastolic ED volumes V can be derived from gated SPECT we intent to study these volumes and their response to dobutamine in order to have a better understanding of the mechanism by which stroke volume SV increases during dobutamine infusion We intent to do this in normal controls and in young diabetic subjectsAfter injection of sestamibi serial gated SPECT were obtained at baseline and during low doses of dobutamine infusion in 12 asymptomatic type I diabetic patients and in 12 age matched controls LV EDV ESV SV and EF were calculated with the QGS programGated SPECT showed comparable LV EF and SV in both groups at rest There was a significant increase in LVEF and SV during dobutamine infusion but in the diabetic patients the increase in SV was due to a decrease in ESV from 25±5 to 20±6 ml/m2 p=0002 and no change in EDV In normal controls the increase in EF was due to an increase in EDV from 69±10 to 73±12 ml/m2 p=0002 with no significant change in ESVThese data confirm the presence of subclinical abnormalities of diastolic function in asymptomatic type I diabetic patients and show differences in adaptation to inotropic stimulation in order to preserve the increase in stroke volume and LV ejection fraction
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