Authors: SeongWook Park MyeongKi Hong Seung Jun Oh Dae Hyuk Moon
Publish Date: 2004/06/16
Volume: 31, Issue: 9, Pages: 1219-1223
Abstract
Stent placement has replaced balloon angioplasty as the most commonly performed percutaneous coronary intervention procedure because of its acute and longterm advantages over balloon angioplasty However widespread use of stents has also led to a new problem the instent restenosis ISR ISR remains a major limitation of stent technology and represents a technical challenge since the recurrence rate after percutaneous intervention is still high particularly for the diffuse type of ISR Studies using intravascular ultrasound have demonstrated that the main mechanism of ISR is neointimal proliferation After innumerable therapeutic failures including systemic drugs new devices and other mechanical approaches intracoronary brachytherapy was established to be the first effective antiproliferative treatment for ISR The predominant vascular response to radiation delivered at the therapeutic doses for intracoronary brachytherapy is chromosomal damage in the vascular
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