Authors: Simone D Jenni Tiziano Schepis Rolf Jenni Patrick T Siegrist Philipp A Kaufmann Tony M Glaus
Publish Date: 2008/09/26
Volume: 36, Issue: 2, Pages: 244-249
Abstract
MBF was measured in nine anaesthetized healthy cats using a PET/CT scanner and 13NH3 at rest and during adenosine infusion Each cat was randomly assigned to receive vasodilator stress with two or three adenosine infusions at the following rates μg/kg per minute 140 Ado 1 standard rate for humans 280 Ado 2 twice the human standard rate 560 Ado 4 840 Ado 6 and 1120 Ado 8The median MBF at rest was 126 ml/min per g n = 9 range 088–172 ml/min per g There was no significant difference at Ado 1 n = 3 median 135 range 093–155 ml/min per g ns but MBF was significantly greater at Ado 2 n = 6 216 range 135–268 ml/min per g p 005 and Ado 4 n = 6 211 192–245 ml/min per g p 005 Large ranges of MBF values at Ado 6 n = 4 253 232–563 ml/min per g ns and Ado 8 n = 3 221 192–570 ml/min per g ns were noted Observed adverse effects including hypotension AVblock and ventricular premature contractions were all mild of short duration and immediately reversed after cessation of the adenosine infusionMBF can be safely measured in cats using PET An intravenous adenosine infusion at a rate of 280 μg/kg per minute seems most appropriate to induce maximal hyperaemic MBF response in healthy cats Higher adenosine rates appear less suitable as they are associated with a large heterogeneity in flow increase and rate pressure product most probably due to the large variability in haemodynamic and heart rate responseWe would like to thank Ratko Milovanovic for data acquisition Sabine BR Kaestner for help with planning and monitoring anaesthesia Claudia E Reusch for helpful discussions Stefan Schellenberg for excellent support in preparing the manuscript and Ingrid Vitali for providing the Maine Coon cats The study was supported by a grant from the Swiss National Science Foundation SNSF professorship grant no PP00A114706
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