Authors: Maria E Campian Hein J Verberne Maxim Hardziyenka Elisabeth A A de Groot Astrid F van Moerkerken Berthe L F van EckSmit Hanno L Tan
Publish Date: 2010/07/06
Volume: 37, Issue: 11, Pages: 2079-2085
Abstract
Arrhythmogenic right ventricular cardiomyopathy/dysplasia ARVC/D is a myocardial disease that predominantly affects the right ventricle RV Its hallmark feature is fibrofatty replacement of RV myocardium However patchy inflammatory infiltrates in the RV are also consistently reported using autopsy and myocardial biopsy Although the role of inflammation in ARVC/D is unresolved the ability to assess inflammation noninvasively may aid in the diagnostic process We aimed to establish whether cardiac inflammation can be assessed noninvasively in ARVC/D patientsARVC/D patients had higher plasma levels than controls of the proinflammatory cytokines interleukin IL1β 122 ± 007 vs 008 ± 001 pg/ml p 00001 IL6 316 ± 044 vs 038 ± 004 pg/ml p 00001 and tumour necrosis factor TNFα 916 ± 090 vs 040 ± 006 pg/ml p 00001 while levels of the antiinflammatory cytokine IL10 were not significantly different 136 ± 015 vs 120 ± 030 pg/ml p = 074 67Ga uptake in the RV was higher in ARVC/D patients than in controls In ARVC/D patients 67Ga uptake in the RV wall was higher than in the interventricular septum or left ventricular wall
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