Authors: Masatoyo Nakajo Megumi Jinguji Yoshiaki Nakabeppu Masayuki Nakajo Ryutarou Higashi Yoshihiko Fukukura Ken Sasaki Yasuto Uchikado Shoji Natsugoe Takashi Yoshiura
Publish Date: 2016/09/10
Volume: 44, Issue: 2, Pages: 206-214
Abstract
The enrolled 52 patients with esophageal cancer underwent 18FFDGPET/CT studies before CRT SUVmax SUVmean metabolic tumour volume MTV SUV ≥ 25 total lesion glycolysis TLG and six heterogeneity parameters assessed by texture analysis were obtained Patients were classified as responders or nonresponders according to Response Evaluation Criteria in Solid Tumors Progressionfree survival PFS and overall survival OS were calculated by the Kaplan–Meier method Prognostic significance was assessed by Cox proportional hazards analysisThirty four nonresponders showed significantly higher MTV p = 0006 TLG p = 0007 intensity variability IV p = 0003 and sizezone variability SZV p = 0004 than 18 responders The positive and negative predictive values for nonresponders were 77 and 69 in MTV 76 and 100 in TLG 78 and 67 in IV and 78 and 82 in SZV respectively Although PFS and OS were significantly shorter in patients with high MTV PFS p = 0018 OS p = 0014 TLG PFS p = 0009 OS p = 0025 IV PFS p = 0013 OS p = 0007 and SZV PFS p = 0010 OS p = 0007 at univariate analysis none of them was an independent factor while lymph node status stage and tumour response status were independent factors at multivariate analysisAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards
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