Authors: Laure Joly Wassila Djaballah Gregory Koehl Damien Mandry Gilles Dolivet PierreYves Marie Athanase Benetos
Publish Date: 2009/01/30
Volume: 36, Issue: 6, Pages: 979-985
Abstract
To analyse the relationship between i aortic pulse wave velocity PWV an index of aortic stiffness with strong prognostic significance and ii aortic calcification and inflammation which were quantified by hybrid imaging with Xray computed tomography CT and 18Ffluorodeoxyglucose FDG positron emission tomography PETIn univariate analyses central aortic PWV was strongly linked to the volume of calcifications VCa and an enhanced FDG activity when determined by averaging standardized uptake values SUVmax By multivariate stepwise analysis including age and gender both VCa p 00001 and SUVmax p 001 were significant determinants of PWV explaining 61 and 11 of its variabilityThis study was performed with the technical support of the Clinical Investigation Center CICINSERM of the University Hospital of Nancy The authors thank ARISC Association de Recherche et Information Scientifique en Cardiologie CHU Nancy for financial support Sylvain Poussier and Henri Boutley for their help in the quantitative analysis of the PET images and Dr Pierre Pothier for language corrections critical review and stimulating discussions
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