Authors: N Kudomi M J Järvisalo J Kiss R Borra A Viljanen T Viljanen T Savunen J Knuuti H Iida P Nuutila P Iozzo
Publish Date: 2009/06/13
Volume: 36, Issue: 12, Pages: 2014-
Abstract
The liver is perfused through the portal vein and hepatic artery Quantification of hepatic glucose uptake HGU using PET requires the use of an input function for both the hepatic artery and portal vein The former can be generally obtained invasively but blood withdrawal from the portal vein is not practical in humans The aim of this study was to develop and validate a new technique to obtain quantitative HGU by estimating the input function from PET imagesNormal pigs n = 12 were studied with 18FFDG PET in which arterial and portal blood timeactivity curves TAC were determined invasively to serve as reference measurements The present technique consisted of two characteristics ie using a model input function and simultaneously fitting multiple liver tissue TACs from images by minimizing the residual sum of square between the tissue TACs and fitted curves The input function was obtained from the parameters determined from the fitting The HGU values were computed by the estimated and measured input functions and compared between the methodsThe estimated input functions were well reproduced The HGU values ranging from 0005 to 002 ml/min per ml were not significantly different between the two methods r = 095 p 0001 A BlandAltman plot demonstrated a small overestimation by the imagederived method with a bias of 000052 ml/min per g for HGUThe authors thank the technical staff of the Turku PET Centre for the efforts and skills dedicated to this project The study was conducted within the “Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research supported by the Academy of Finland University of Turku Turku University Hospital and Abo Academy This work is part of the project Hepatic and Adipose Tissue and Functions in the Metabolic Syndrome HEPADIP which is supported by the European Commission as an Integrated Project under the 6th Framework Programme contract LSHMCT2005018734 The study was further supported by grants from the Finnish Diabetes Foundation PI EFSD/EliLilly PI Sigrid Juselius Foundation NK and Novo Nordisk Foundation PN
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