Authors: Mathieu Gauthé Marion RichardMolard Juliette Fayard JeanLouis Alberini Wulfran Cacheux Astrid Lièvre
Publish Date: 2016/08/09
Volume: 44, Issue: 1, Pages: 63-70
Abstract
Patients with a recent diagnosis of SCC of the anal canal without metastases undergoing PET/CT for initial workup and treated with chemoradiotherapy were retrospectively reviewed Computeraided MTV and SUVmax were determined Survival rates were estimated using the KaplanMeier method Cox regression analysis was used to evaluate prognostic variables of progressionfree survival and overall survival OSThe study group comprised 75 patients who had an initial workup PET/CT Five patients 67 had stage I disease 22 293 stage II disease 20 267 stage IIIA disease and 28 373 stage IIIB disease Median followup was 51 months range 10 – 117 months Global 4year OS was 827 ranging from 100 in patients with stage I disease to 75 in patients with stage IIIB disease MTV at the primary site was significantly and independently correlated with OS p 005 as patients with MTV less than 7 cm3 had a better prognosis SUVmax was not correlated with survival parameters Metabolic involvement of the inguinal lymph nodes was also correlated with a poor outcome in the univariate analysis p 005
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