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Journal Title

Title of Journal: Eur J Nucl Med Mol Imaging

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Abbravation: European Journal of Nuclear Medicine and Molecular Imaging

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Springer Berlin Heidelberg

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DOI

10.1016/j.amjsurg.2005.01.018

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ISSN

1619-7089

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Metabotropic glutamate receptor 5 – a promising ta

Authors: Rajapillai L I Pillai Dnyanesh N Tipre
Publish Date: 2016/01/07
Volume: 43, Issue: 6, Pages: 1151-1170
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Abstract

This review summarizes the contributions by various teams of scientists in assessing the metabotropic glutamate receptor 5 mGluR5 as a biomarker in neuropsychiatric disorders and diseases Development of positive and negative allosteric modulators of mGluR5 is reviewed as is the development of PET radioligands that have the potential to measure mGluR5 receptor density in neurological disorders and during therapeutic interventions PET imaging provides an effective tool to assess the specificity of new drugs select dose regimens in clinical trials and study drug mechanisms of action We summarize and deliver comparative analyses of mGluR5specific PET radiotracers and their applications in understanding the pathophysiology of mGluR5related nervous system disorders and to speed up drug development

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