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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer-Verlag

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DOI

10.1007/s11082-005-8338-4

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1435-1463

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Nicotinic receptors and cognition in Parkinson’s D

Authors: P B Forgacs I BodisWollner
Publish Date: 2004/06/30
Volume: 111, Issue: 10-11, Pages: 1317-1331
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Abstract

Parkinson’s Disease PD is associated with cognitive deficits The earliest impairment is evident for executive abilities visuospatial orientation and memory Dopamine deficiency is unlikely to be singly responsible for all cognitive changes in PD Acetylcholine has an essential role in cognition thus cholinergic transmission may have an important role in nondopaminergic cognitive changes If so some cognitive defects could possibly be treated with cholineesterase inhibitors A concern is the potential negative motor effect of cholinergic medication in PD Surprisingly these are reported only in a few patients studied Establishing the relationship between select cognitive deficits and nicotinic neurotransmission may lay the foundation for rational pharmacotherapy of cognitive dysfunction in PDWe summarize anatomical physiological and pharmacological aspects of nicotinic receptor function The focus is on those nicotine receptor dependent cognitive dysfunctions which are likely to contribute to motor impairment Lastly we discuss hypotheses concerning cholinergic involvement in neuronal synchrony and sensorimotor integration in PD

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  2. Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro
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  4. CSF markers of neurodegeneration in Parkinson’s disease
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  7. The effects of buffer cations on interactions between mammalian copper-containing amine oxidases and their substrates
  8. Psychiatric disorders in adults diagnosed as children with atypical autism. A case control study
  9. Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
  10. How does healthy aging impact on the circadian clock?
  11. Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease
  12. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese
  13. Kynurenines in Parkinson’s disease: therapeutic perspectives
  14. Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain
  15. L-DOPA inhibits depolarization-induced [ 3 H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors
  16. Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice
  17. Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
  18. The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach
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  41. Editorial
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