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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer Vienna

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ISSN

1435-1463

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Increase expression of αsynuclein in aged human b

Authors: Qi Xuan ShengLi Xu DeHong Lu Shun Yu Ming Zhou Kenji Uéda YeQing Cui BoYang Zhang Piu Chan
Publish Date: 2011/04/03
Volume: 118, Issue: 11, Pages: 1575-1583
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Abstract

Although the increased prevalence of Parkinson’s disease PD with aging suggests that aging processes predispose dopamine neurons to degeneration the mechanism involved remains unknown Dopamine neurons contain significant amounts of neuromelanin and the amount of neuromelanin increases with aging In the present study agerelated changes in the number of nigral neurons expressing neuromelanin NM αsynuclein and tyrosine hydroxylase TH were stereologically analyzed in the postmortem brains of 28 healthy humans with an age range of 17–84 years Stereological counting of NM content αsynuclein content and TH immunoreactivity revealed significant accumulation of NM and αsynuclein in neurons during the aging process In cells containing a large amount of NM αsynucleinimmunoreactive cells in aged individuals outnumbered those of younger individuals In nonNM cells the αsynuclein expression profile was similar across age groups Furthermore THimmunoreactive neurons decreased significantly with aging which was associated with accumulation of NM and αsynuclein Our results suggest that age related accumulation of NM might induce αsynuclein overexpression and thereby make dopamine neurons more vulnerable to injuriesThis study was supported by grants from the Major State Basic Research Development Program of China 973 program No 2006CB500701 the National High Technology Research and Development Program of China 863 program No 2006AA02A408 and the National Natural Science Foundation of China No 30671950 30430280

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