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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer Vienna

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DOI

10.1007/978-3-319-13105-4_49

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1435-1463

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Association between ACE polymorphism cognitive ph

Authors: Afef AchouriRassas Nadia Ben Ali Aroua Cherif Saloua Fray Hajer Siala Nouria Oudiaa Zakraoui Sondes HadjFredj Mariem Kechaou Nadia Anane Slim Echebi Taieb Messaoud Samir Belal
Publish Date: 2015/10/12
Volume: 123, Issue: 3, Pages: 317-321
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Abstract

Angiotensinconverting enzyme ACE has shown altered activity in patients with neurological diseases An insertion/deletion I/D polymorphism of the ACE gene encoding angiotensinconverting enzyme has been reported to be associated with the risk for Alzheimer’s disease AD and is generally considered to be a disorder primarily affecting memory We conducted a case–control study in a sample composed of 85 sporadic AD patients and 90 age and sexmatched controls to investigate the possible effect of the polymorphism and cognitive profile Our data revealed an association between the ACE polymorphism and AD risk There was a significant difference in the ACE allele or genotype frequencies between cases and controls The D/D genotype showed an increased risk for AD and in the amnestic group and the effect was independent on ApoE genotypesThis work was funded by the Ministry of Higher Education and Scientific Research in Tunisia Faculté de médecine Tunis Research Laboratory “temporal lobe pathology” CHU Charles Nicolle Tunis This project is conducted within the framework of MOBIDOCPost doc as specified in PASRI program funded by the EU and managed by the ANPR

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