Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Neural Transm

Search In Journal Title:

Abbravation: Journal of Neural Transmission

Search In Journal Abbravation:

Publisher

Springer-Verlag

Search In Publisher:

DOI

10.1007/bf02785557

Search In DOI:

ISSN

1435-1463

Search In ISSN:
Search In Title Of Papers:

Both endogenous and exogenous ACh plays antinocice

Authors: X F Yang Y Xiao MY Xu
Publish Date: 2007/09/14
Volume: 115, Issue: 1, Pages: 1-6
PDF Link

Abstract

The present study examines the effect of acetylcholine ACh muscarinic acetylcholine receptors mAChRs agonist pilocarpine and mAChRs antagonist atropine on the painevoked response of painexcited neurons PEN and paininhibited neurons PIN in the hippocampal CA1 of rats The trains of electric impulses applied to the sciatic nerve were used as noxious stimulation The discharges of PEN and PIN in the hippocampal CA1 were recorded by glass microelectrode The results showed that intrahippocampal microinjection of ACh 2 µg/1 µl or pilocarpine 2 µg/1 µl decreased the frequency of discharge of PEN and increased the frequency of discharge of PIN evoked by the noxious stimulation in the hippocampal CA1 while intrahippocampal administration of atropine 05 µg/1 µl produced opposite response On the basis of the above findings we can deduce that ACh and mAChRs are involved in the modulation of nociceptive information transmission in the hippocampal CA1

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. A distinct variant of mixed dysarthria reflects parkinsonism and dystonia due to ephedrone abuse
  2. Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro
  3. Should magnesium be given to every migraineur? No
  4. CSF markers of neurodegeneration in Parkinson’s disease
  5. CSF markers of neurodegeneration in Parkinson’s disease
  6. Region-specific causal mechanism in the effects of ammonia on cerebral glucose metabolism in the rat brain
  7. The effects of buffer cations on interactions between mammalian copper-containing amine oxidases and their substrates
  8. Psychiatric disorders in adults diagnosed as children with atypical autism. A case control study
  9. Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
  10. How does healthy aging impact on the circadian clock?
  11. Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease
  12. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese
  13. Kynurenines in Parkinson’s disease: therapeutic perspectives
  14. Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain
  15. L-DOPA inhibits depolarization-induced [ 3 H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors
  16. Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice
  17. Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
  18. The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach
  19. Does exposure to extremely low frequency magnetic fields produce functional changes in human brain?
  20. New insights into the structures and functions of human monoamine oxidases A and B
  21. DBS in Tourette syndrome: where are we standing now?
  22. Association between the RAGE G82S polymorphism and Alzheimer’s disease
  23. Differential modulation of alpha-1 adrenoceptor subtypes by antidepressants in the rat brain
  24. CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD
  25. Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens
  26. Effects of extracellular pH reductions on [ 3 H] d -aspartate and [ 3 H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex
  27. Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
  28. Effects of dopaminergic replacement therapy on motor speech disorders in Parkinson’s disease: longitudinal follow-up study on previously untreated patients
  29. Dopamine differently modulates central cholinergic circuits in patients with Alzheimer disease and CADASIL
  30. Nicotinic receptors and cognition in Parkinson’s Disease: the importance of neuronal synchrony
  31. Forty-two-years later: the outcome of childhood-onset schizophrenia
  32. Potential therapeutic system for Alzheimer’s disease: removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal-failure patients
  33. Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test
  34. The contribution of white matter lesions to Parkinson’s disease motor and gait symptoms: a critical review of the literature
  35. Facilitative effects of VNS on the motor threshold: implications for its antidepressive mode of action?
  36. Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study
  37. Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson’s disease
  38. Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson’s disease
  39. Time-dependent behavioral recovery after pneumococcal meningitis in rats
  40. Atrial fibrillation and stroke prevention: is warfarin still an option? Yes
  41. Editorial
  42. Bright light therapy in the treatment of childhood and adolescence depression, antepartum depression, and eating disorders
  43. Screening of two indel polymorphisms in the 5′UTR of the DJ - 1 gene in South African Parkinson’s disease patients
  44. Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse
  45. MR and GR functional SNPs may modulate tobacco smoking susceptibility
  46. The deep brain stimulation of the pedunculopontine tegmental nucleus: towards a new stereotactic neurosurgery
  47. Factors affecting the relative importance of amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans
Search Result: