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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Publisher

Springer Vienna

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DOI

10.1007/bf01750581

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ISSN

1435-1463

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Change in the expression of myelination/oligodendr

Authors: Tadasu Matsuoka Tomiki Sumiyoshi Masahiko Tsunoda Ichiro Takasaki Yoshiaki Tabuchi Takashi Uehara Hiroko Itoh Michio Suzuki Masayoshi Kurachi
Publish Date: 2010/08/27
Volume: 117, Issue: 11, Pages: 1265-1268
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Abstract

Agedependent changes of gene expression in the prefrontal cortex PFC of rats around the time of puberty were investigated by means of microarray and quantitative polymerase chain reaction qPCR About 127 and 138 genes were increased and decreased respectively in the PFC of rats at postpuberty PD56 compared with those at prepuberty PD35 Functional analysis showed significant associations of these genes with aging cellular development and neuropsychological disorders qPCR analysis confirmed downregulation of seven genes related to myelination As these genes have been reported to be diminished in the brain of patients with schizophrenia the results of this study suggest an exaggerated maturation process may contribute to the pathogenesis of psychotic disorders

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