Paper Search Console

Home Search Page About Contact

Journal Title

Title of Journal: J Neural Transm

Search In Journal Title:

Abbravation: Journal of Neural Transmission

Search In Journal Abbravation:

Publisher

Springer Vienna

Search In Publisher:

DOI

10.1002/hyp.10740

Search In DOI:

ISSN

1435-1463

Search In ISSN:
Search In Title Of Papers:

A distinct variant of mixed dysarthria reflects pa

Authors: Jan Rusz Marika Megrelishvili Cecilia Bonnet Michael Okujava Hana Brožová Irine Khatiashvili Madona Sekhniashvili Marina Janelidze Eduardo Tolosa Evžen Růžička
Publish Date: 2014/01/21
Volume: 121, Issue: 6, Pages: 655-664
PDF Link

Abstract

A distinctive alteration of speech has been reported in patients suffering from ephedroneinduced parkinsonism However an objective assessment of dysarthria has not been performed in ephedrone users We studied 28 young Caucasian men from Georgia with a previous history of ephedrone abuse and compared them to 25 agematched healthy controls Speech examination brain MRI and NNIPPSParkinson plus scale were performed in all patients The accurate differential diagnosis of dysarthria subtypes was based on the quantitative acoustic analyses of 15 speech dimensions We revealed a distinct variant of mixed dysarthria with a combination of hyperkinetic and hypokinetic components representing the altered motor programming of dystonia and bradykinesia in ephedroneinduced parkinsonism According to acoustic analyses all patients presented at least one affected speech dimension whereas dysarthria was moderate in 43  and severe in 36  of patients Further findings indicated relationships between motor subscores of dystonia and bradykinesia and speech components of loudness r = −054 p  001 articulation r = 040 p  005 and timing r = −053 p  001 In ephedroneinduced parkinsonism a prominent mixed hyperkinetic–hypokinetic dysarthria occurs that appears related to marked dystonia and bradykinesia and probably reflects manganese induced toxic and neurodegenerative damage to the globus pallidus internus and substantia nigraWe are grateful to H E Ivan Jestrab the Czech Ambassador in Georgia for his personal support to Nina Mikeladze for neuropsychological testing of patients to Prof Jonas Bergquist for testing the manganese content of patient hair to Prof Giorgi Menabde for his support and to Aaron Rulseh MD for his thoughtful English corrections This study was supported by the Czech Science Foundation GACR 102/12/2230 Czech Ministry of Health NT/122885 and NT/141813 and Charles University in Prague PRVOUKP26/LF1/4 and GA UK 441611 MRI examination in the Research Institute of Clinical Medicine in Tbilisi was enabled by the grant from the Czech Development Agency JSC Bank Republic Tbilisi supported customs expenses

Keywords:

References

.
Search In Abstract Of Papers:
Other Papers In This Journal:
  1. Effects of cholinesterase inhibitors on rat nicotinic receptor levels in vivo and in vitro
  2. Should magnesium be given to every migraineur? No
  3. CSF markers of neurodegeneration in Parkinson’s disease
  4. CSF markers of neurodegeneration in Parkinson’s disease
  5. Region-specific causal mechanism in the effects of ammonia on cerebral glucose metabolism in the rat brain
  6. The effects of buffer cations on interactions between mammalian copper-containing amine oxidases and their substrates
  7. Psychiatric disorders in adults diagnosed as children with atypical autism. A case control study
  8. Increase expression of α-synuclein in aged human brain associated with neuromelanin accumulation
  9. How does healthy aging impact on the circadian clock?
  10. Association between ACE polymorphism, cognitive phenotype and APOE E4 allele in a Tunisian population with Alzheimer disease
  11. TMEM106B and APOE polymorphisms interact to confer risk for late-onset Alzheimer’s disease in Han Chinese
  12. Kynurenines in Parkinson’s disease: therapeutic perspectives
  13. Change in the expression of myelination/oligodendrocyte-related genes during puberty in the rat brain
  14. L-DOPA inhibits depolarization-induced [ 3 H]GABA release in the dopamine-denervated globus pallidus of the rat: the effect is dopamine independent and mediated by D2-like receptors
  15. Damage to oligodendrocytes in the striatum after MPTP neurotoxicity in mice
  16. Exercise inhibits neuronal apoptosis and improves cerebral function following rat traumatic brain injury
  17. The PROMESA-protocol: progression rate of multiple system atrophy under EGCG supplementation as anti-aggregation-approach
  18. Does exposure to extremely low frequency magnetic fields produce functional changes in human brain?
  19. New insights into the structures and functions of human monoamine oxidases A and B
  20. DBS in Tourette syndrome: where are we standing now?
  21. Association between the RAGE G82S polymorphism and Alzheimer’s disease
  22. Differential modulation of alpha-1 adrenoceptor subtypes by antidepressants in the rat brain
  23. CSF and clinical hallmarks of subcortical dementias: focus on DLB and PDD
  24. Stimulation of D2 receptors in the prefrontal cortex reduces PCP-induced hyperactivity, acetylcholine release and dopamine metabolism in the nucleus accumbens
  25. Effects of extracellular pH reductions on [ 3 H] d -aspartate and [ 3 H]noradrenaline release by presynaptic nerve terminals isolated from rat cerebral cortex
  26. Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
  27. Effects of dopaminergic replacement therapy on motor speech disorders in Parkinson’s disease: longitudinal follow-up study on previously untreated patients
  28. Both endogenous and exogenous ACh plays antinociceptive role in the hippocampus CA1 of rats
  29. Dopamine differently modulates central cholinergic circuits in patients with Alzheimer disease and CADASIL
  30. Nicotinic receptors and cognition in Parkinson’s Disease: the importance of neuronal synchrony
  31. Forty-two-years later: the outcome of childhood-onset schizophrenia
  32. Potential therapeutic system for Alzheimer’s disease: removal of blood Aβs by hemodialzyers and its effect on the cognitive functions of renal-failure patients
  33. Influence of diltiazem on the behavior of zolpidem-treated mice in the elevated-plus maze test
  34. The contribution of white matter lesions to Parkinson’s disease motor and gait symptoms: a critical review of the literature
  35. Facilitative effects of VNS on the motor threshold: implications for its antidepressive mode of action?
  36. Association between circadian rhythms, sleep and cognitive impairment in healthy older adults: an actigraphic study
  37. Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson’s disease
  38. Mutation analysis of the seven in absentia homolog 1 (SIAH1) gene in Parkinson’s disease
  39. Time-dependent behavioral recovery after pneumococcal meningitis in rats
  40. Atrial fibrillation and stroke prevention: is warfarin still an option? Yes
  41. Editorial
  42. Bright light therapy in the treatment of childhood and adolescence depression, antepartum depression, and eating disorders
  43. Screening of two indel polymorphisms in the 5′UTR of the DJ - 1 gene in South African Parkinson’s disease patients
  44. Kainate receptor-mediated presynaptic inhibition converges with presynaptic inhibition mediated by Group II mGluRs and long-term depression at the hippocampal mossy fiber-CA3 synapse
  45. MR and GR functional SNPs may modulate tobacco smoking susceptibility
  46. The deep brain stimulation of the pedunculopontine tegmental nucleus: towards a new stereotactic neurosurgery
  47. Factors affecting the relative importance of amine oxidases and monooxygenases in the in vivo metabolism of xenobiotic amines in humans
Search Result: