Authors: Masao Kato Kazunori Kawaguchi Sigeru Nakai Kazutaka Murakami Hideo Hori Atsushi Ohashi Yoshiyuki Hiki Shinji Ito Yasunobu Shimano Nobuo Suzuki Satoshi Sugiyama Hiroshi Ogawa Hiroko Kusimoto Tatsuro Mutoh Yukio Yuzawa Nobuya Kitaguchi
Publish Date: 2012/06/15
Volume: 119, Issue: 12, Pages: 1533-1544
Abstract
The pathological changes of Alzheimer’s disease include the deposition of amyloid β protein Aβ as senile plaques in the brain We hypothesized that the rapid removal of Aβs from the blood may act as a peripheral Aβ drainage sink from the brain In this study the plasma Aβ concentrations and the cognitive functions were investigated for in 57 patients on hemodailysis 694 ± 38 years 26 renalfailure patients without hemodialysis 666 ± 147 years and 17 agematched healthy controls 666 ± 41 years The concentrations of plasma Aβs increased along with the decline of renal functions Moreover the renalfailure patients without hemodialysis and with poorer renal functions showed lower cognitive functions The plasma concentrations of Aβ142 correlated with serum creatinine P 0001 and MiniMentalState Examination scores P = 0017 The dialyzers effectively removed Aβs in the blood during hemodialysis sessions The plasma Aβ concentrations showed steady or slightly decreasing along with duration of hemodialysis The total amount of Aβs removed during a hemodialysis session was calculated to be comparable to the Aβs dissolved in the blood and the cerebrospinal fluid The MMSE scores of the hemodialysis patients showed no clear decrease in longer hemodialysis duration Therefore the therapeutic approach for Alzheimer’s disease by removing Aβs from the blood is worthy of further investigation including whether or not Aβs in the brain decreaseThe authors sincerely thank Dr Shigenobu Nakamura for his fruitful discussions The authors also thank Ms Yukari Murata and Sachi Oguri for their technical assistance This work was partly supported by KAKENHI 20509008 and 23500531 and the Smoking Research Foundation
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