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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer-Verlag

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DOI

10.1002/asia.201402900

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1435-1463

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LDOPA inhibits depolarizationinduced Superscri

Authors: I Silva H Cortes E Escartín C Rangel L Florán D Erlij J Aceves B Florán
Publish Date: 2006/06/01
Volume: 113, Issue: 12, Pages: 1847-1853
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Abstract

The effect of LDOPA on 3HGABA release in slices of globus pallidus from 6OHDAlesioned rats was studied Release was evoked by high 15 mM K+ The lesion reduced dopamine content and dopamine synthesized from LDOPA The inhibition of DOPA decarboxylase blocked dopamine synthesis Endogenous dopamine released by high K+ inhibited 3HGABA release in normal but not in lesioned slices LDOPA inhibited IC50 = 044 µM evoked 3HGABA release The inhibition was via D2like receptors but not mediated by dopamine The turning behavior induced by LDOPA methyl ester 25 mg/kg ip was not abolished by the DOPA decarboxylase inhibitor 3hydroxybenzylhydrazine but in this condition it was abolished by sulpiride Results suggest that LDOPA acting as D2like agonist inhibits GABA release in the rat globus pallidus and induces turning behavior in rats with unilateral lesions of the dopamine innervation LDOPA could control Parkinson’s disease symptoms acting not only as dopamine precursor but also by itself

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