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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Publisher

Springer Vienna

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DOI

10.1007/bf03002461

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ISSN

1435-1463

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Timedependent behavioral recovery after pneumococ

Authors: Tatiana Barichello Geruza Z Silva Jaqueline S Generoso Geovana D Savi Cleonice M Michelon Gustavo Feier Clarissa M Comim João Quevedo
Publish Date: 2010/06/18
Volume: 117, Issue: 7, Pages: 819-826
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Abstract

Alterations in hippocampus frequently occur following bacterial meningitis despite antibiotic treatment We investigated the cognitive performance in rats submitted to bacterial meningitis after 10 30 and 60 days To this aim we utilized male Wistar rats submitted to either sham control or meningitis by Streptococcus pneumoniae and followed by the initiation of the antibiotic treatment at 16 h after inoculation The animals underwent six behavioral tasks 10 30 and 60 days after surgery We demonstrated that some of the learning and memory impairment demonstrated 10 days after the induction of meningitis persists up to 30 days but not 60 days after induction

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