Authors: Hana Přikrylová Vranová Jan Mareš Martin Nevrlý David Stejskal Jana Zapletalová Petr Hluštík Petr Kaňovský
Publish Date: 2010/08/21
Volume: 117, Issue: 10, Pages: 1177-1181
Abstract
Parkinson’s disease PD is a chronic progressive neurodegenerative disease with a multifactorial etiology Protein accumulation is speculated by some to play a prominent role in the pathogenesis of PD The severity of neurodegeneration should correlate with cerebrospinal fluid CSF levels of these neurodegenerative markers NDMs The aims of the study were to assess the CSF levels of tau protein betaamyloid 1–42 cystatin C and clusterin in patients suffering from PD and in a control group to compare the CSF levels between the two groups and to correlate them to PD duration NDMs in the CSF were assessed in 32 patients suffering from PD and in a control group CG of 30 patients The following statistically significant differences in the CSF were found higher tau protein p = 0045 and clusterin levels p = 0004 in PD patients versus CG higher tau protein levels p = 0033 tau protein/betaamyloid 1–42 ratio p = 0011 and clusterin p = 0044 in patients suffering from PD for 2 years versus patients suffering PD for more than 2 years No differences between betaamyloid 1–42 and cystatin C CSF levels were found in the CG and PD patients groups Significantly higher tau protein and clusterin CSF levels in the group of PD patients with disease duration of 2 years probably reflect the fact that most neurodegenerative changes in PD patients occur in the initial stage of disease
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