Authors: J V NegreteDíaz T S Sihra J M DelgadoGarcía A RodríguezMoreno
Publish Date: 2007/05/18
Volume: 114, Issue: 11, Pages: 1425-1431
Abstract
Kainate receptors KARs effect depression of glutamate release at hippocampal mossy fiberCA3 MFCA3 synapses by a metabotropic action involving adenylyl cyclase AC inhibition cAMP reduction and diminished protein kinase A PKA activation Using hippocampal slices we show here that KAR activation interferes with the depression of glutamate release produced by Group II metabotropic glutamate receptor stimulation and low frequency stimulation LFSinduced longterm depression LTD also expressed through presynaptic AC/cAMP/PKA at MFCA3 synapses The mutual occlusion of depression mediated by presynaptic KARs Group II mGluR and LFSinduced LTD suggests their mechanistic convergence at the MFCA3 synapse and thus invokes KARs in synaptic plasticity manifest in LTD
Keywords: