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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer Vienna

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1435-1463

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Kynurenines in Parkinson’s disease therapeutic pe

Authors: Dénes Zádori Péter Klivényi József Toldi Ferenc Fülöp László Vécsei
Publish Date: 2011/08/20
Volume: 119, Issue: 2, Pages: 275-283
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Abstract

Parkinson’s disease PD is a chronic progressive neurodegenerative disorder the pathomechanism of which is not yet fully known With regard to the molecular mechanism of development of the disease oxidative stress/mitochondrial impairment glutamate excitotoxicity and neuroinflammation are certainly involved Alterations in the kynurenine pathway the main pathway of the tryptophan metabolism can contribute to the complex pathomechanism There are several possibilities for therapeutic intervention involving targeting of this altered metabolic route The development of synthetic molecules that would shift the altered balance towards the achievement of neuroprotective effects would be of great promise for future clinical studies on PDThis work was supported by grants ETT 02604 and TÁMOP421/B09/1/KONV20100005 The project “TÁMOP421/B09/1/KONV20100005—Creating the Center of Excellence at the University of Szeged” is supported by the European Union and cofinanced by the European Regional Development Fund

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