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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer Vienna

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DOI

10.1016/0167-5273(87)90218-X

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ISSN

1435-1463

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Association between the RAGE G82S polymorphism and

Authors: Keshen Li Dawei Dai Bin Zhao Lifen Yao Songpo Yao Binyou Wang Ze Yang
Publish Date: 2009/11/10
Volume: 117, Issue: 1, Pages: 97-
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Abstract

The receptor for advanced glycation end products RAGE is associated with several pathological states including Alzheimer’s disease AD pathology while its soluble form sRAGE acts as a decoy receptor We have tested for association of AD with a functional singlenucleotide polymorphism SNP in the RAGE gene G82S rs2070600 a SNP associated with increased ligand affinity of RAGE Analysis of a Chinese cohort 276 cases 254 controls showed a higher prevalence of the RAGE 82S allele and GS + SS genotype in the patients 82S vs 82G P = 0017 odds ratio OR = 1431 GS + SS vs GG P = 0025 OR = 1490 Further stratification analysis revealed that the association of the RAGE G82S polymorphism with AD was significant in early onset AD stratum Moreover plasma sRAGE levels were lower in AD than in normal elderly controls and the presence of the risk allele was associated with further plasma sRAGE reduction and a fast cognitive deterioration The present study provides preliminary evidence that the RAGE G82S variant is involved in genetic susceptibility to AD

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