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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer-Verlag

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DOI

10.1016/0278-2391(83)90031-9

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1435-1463

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Factors affecting the relative importance of amine

Authors: M Strolin Benedetti K F Tipton R Whomsley E Baltes
Publish Date: 2007/03/31
Volume: 114, Issue: 6, Pages: 787-
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Abstract

The monooxygenases and the amine oxidases AOs are the major enzyme systems involved in vivo in the oxidative metabolism of xenobiotic amines in humans With the exception of the inhibition of the metabolism of tyramine ingested by subjects taking inhibitors of MAOA or of both MAOA and B which has been extensively investigated the involvement of the monoamine oxidases in xenobiotic amine metabolism drugs in particular has been largely neglected Furthermore with the exception of amlodipine there have been essentially no studies on the metabolism of drug amines by amine oxidases such as SSAOs and PAOs in humans In contrast monooxygenases CYP isoenzymes and to a lesser extent FMOs have been extensively investigated in terms of their involvement in xenobiotic metabolism It is possible that the contribution of AOs to the overall metabolism of xenobiotic amines in humans has been underestimated or erroneously estimated as most investigations of drug metabolism have been performed using in vitro test systems optimized for CYP activity such as liver microsomes and most investigations of drug metabolism in vivo in humans have identified only the final stable metabolites

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