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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer-Verlag

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DOI

10.1007/bf03242953

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1435-1463

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Influence of diltiazem on the behavior of zolpidem

Authors: XY Cui X Zhao QP Chu BQ Chen YH Zhang
Publish Date: 2006/08/01
Volume: 114, Issue: 2, Pages: 155-
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Abstract

The present study was undertaken to investigate the effect of diltiazem a Ltype calcium channel blocker CCB on the behavior of zolpidemtreated mice in the elevated plusmaze EPM Atypical benzodiazepine zolpidem significantly increased the percentage of open arm entries without influencing the total entries and total distance and average speed at the dose of 5 mg/kg po Coadministration of zolpidem 2 mg/kg po and diltiazem 5 10 and 20 mg/kg po significantly increased both the time spent and arm entries in the open arms without influencing the total entries and spontaneous activity notwithstanding that zolpidem at dose up to 2 mg/kg po and diltiazem at dose up to 20 mg/kg po did not show any effects on mice behavior in EPM Zolpidem also attenuated the anxiogenic effect of 13Chlorophenylpiperazine mCPP 07 mg/kg ip and 5hydroxytryptophan 5HTP 30 mg/kg ip Even though the zolpidem at 1 mg/kg and diltiazem at 5 mg/kg were ineffective on mCPPinduced anxiety respectively the coadministration of zolpidem 1 mg/kg ip and diltiazem 5 mg/kg po showed inhibitory effect on mCPPinduced anxiety in mice These results suggested that diltiazem a Ltype CCB may augment the anxiolyticlike effect of zolpidem and also indicated that calcium channel modulation maybe involved in the anxiolyticlike properties of zolpidem

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