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Title of Journal: J Neural Transm

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Abbravation: Journal of Neural Transmission

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Springer-Verlag

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DOI

10.1002/dev.420260804

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1435-1463

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Stimulation of D2 receptors in the prefrontal cort

Authors: A Del Arco F Mora A H Mohammed K Fuxe
Publish Date: 2006/08/08
Volume: 114, Issue: 2, Pages: 185-193
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Abstract

The aim of the present study was to investigate the effects of stimulation of D2 receptors in the prefrontal cortex PFC on spontaneous motor activity and the hyperactivity induced by the psychomimetic phencyclidine PCP In addition the effects of prefrontal D2 stimulation under PCP treatment on dialysate concentrations of acetylcholine choline dopamine DOPAC and HVA in the nucleus accumbens were also investigated SpragueDawley male rats were implanted with guide cannulae to perform bilateral injections into the medial PFC of the D2 agonist quinpirole 15 and 5 µg/side Horizontal and vertical spontaneous motor activity and the motor activity induced by systemic injections of the PCP 5 mg/kg ip were monitored in the open field PFC injections of quinpirole 15 and 5 µg/side significantly decreased horizontal and vertical spontaneous motor activity in a doserelated manner These effects were blocked by the D2 antagonist raclopride 5 µg/side Microinjections of quinpirole 15 and 5 µg/side into the PFC also significantly attenuated the hyperactivity produced by PCP 5 mg/kg ip PCP also increased dialysate concentrations of acetylcholine and dopamine metabolites in the nucleus accumbens These increases were also reduced by injections of quinpirole 5 µg/side into the PFC These results suggest that the stimulation of prefrontal D2 receptors plays an inhibitory role in regulating spontaneous and PCPinduced motor activity and also in the neurochemical changes produced by PCP in the nucleus accumbens

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