Authors: RuiChun Lu Hao Wang MengShan Tan JinTai Yu Lan Tan
Publish Date: 2013/10/29
Volume: 121, Issue: 3, Pages: 283-287
Abstract
Recent large genomewide association studies have found variants in TMEM106B top SNP rs1990622 as a strong risk factor for frontotemporal lobar degeneration Moreover the TMEM106B risk variant is also implicated in the pathologic presentation of Alzheimer’s disease AD Here we evaluated the association between TMEM106B rs1990622 polymorphism and lateonset AD LOAD in a Northern Han Chinese population consists of 1133 LOAD patients and 1159 controls Our data demonstrate that TMEM106B and APOE interact to increase AD risk
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