Authors: FangTing Kuo Kenneth Fan Gayane Ambartsumyan Priya Menon Aline Ketefian Ikuko K BentsiBarnes Margareta D Pisarska
Publish Date: 2011/07/16
Volume: 28, Issue: 10, Pages: 931-938
Abstract
SMAD17 and 9 are expressed in human granulosa cells with SMAD2 3 and 4 showing the highest expression levels Peak estradiol E2 levels correlated with the number of oocytes retrieved during IVF Oocyte number showed no correlation with SMAD expression levels or ratios Fertilization rates also did not correlate with the expression levels of individual SMADs but did correlate with higher SMAD4SMAD3 ratios p = 00062 and trended with SMAD4SMAD2 p = 00698SMAD transcripts are differently expressed in human granulosa cells where they may mediate TGFbeta superfamily signaling during folliculogenesis and ovulation Further the relative expression ratios of SMAD2 3 and 4 may differentially affect fertilization rate
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