Authors: Jamie A Grifo Brooke HodesWertz HsiaoLing Lee Esmeralda Amperloquio Melicia ClarkeWilliams Alexis Adler
Publish Date: 2013/01/11
Volume: 30, Issue: 2, Pages: 259-264
Abstract
The objective of our study was to determine if trophectoderm biopsy vitrification arraycomparative genomic hybridization and single thawed euploid embryo transfer STEET can reduce multiple gestations and yield high pregnancy and low miscarriage ratesWe performed a retrospective observational study comparing single thawed euploid embryo to routine age matched in vitro fertilization IVF patients that underwent blastocyst transfer from 2008 to 2011 and to our best prognosis group donor oocyte recipients Donor Our main outcome measures were implantation rate clinical pregnancy rate spontaneous abortion rate and multiple gestation rateThe STEET group had a significantly higher implantation rate 58 53/91 than the routine IVF group 39 237/613 while the Donor group 57 387/684 had a similar implantation rate The clinical pregnancy rates were not statistically different between the STEET and IVF groups However the multiple gestation rate was significantly lower in the STEET group STEET 2 versus IVF 34 Donor 47 STEET results in a high pregnancy rate low multiple gestation rate and miscarriage rates Despite the older age of STEET patients and transfer of twice as many embryos the implantation rate for STEET was indistinguishable from that for egg donation STEET offers an improvement to IVF lowering risks without compromising pregnancy rate
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