Authors: Fernanda Mafra Michele Catto Bianca Bianco Caio Parente Barbosa Denise Christofolini
Publish Date: 2015/07/03
Volume: 32, Issue: 9, Pages: 1359-1364
Abstract
Recently several genomewide association studies have demonstrated an association between endometriosis and markers located in or near to WNT4 gene In order to assess the validity of the findings we conducted a replication case–control study in a Brazilian populationGenetic association study comprising 400 infertile women with endometriosis and 400 fertile women as controls TaqMan allelic discrimination technique was used to investigate the relationship between endometriosis and four singlenucleotide polymorphisms rs16826658 rs3820282 rs2235529 and rs7521902 in WNT4 gene Genotype distribution allele frequency and haplotype analysis of the WNT4 polymorphisms were performed A p value 005 was considered significantThe results revealed a significant association of rs16826658 p = 7e04 and rs3820282 p = 0048 singlenucleotide polymorphisms SNPs on WNT4 gene with endometriosisrelated infertility while rs2235529 and rs7521902 SNPs showed no difference between cases and controlsOur results suggested that rs16826658 and rs3820282 polymorphisms on WNT4 gene might be involved in the pathogenesis of endometriosis in the infertile women studied Analysis of WNT4 genetic variants might help to identify patients at high risk for disease development
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