Authors: Radia Boudjenah Denise MolinaGomes Robert Wainer Philippe de Mazancourt Jacqueline Selva François Vialard
Publish Date: 2012/10/27
Volume: 29, Issue: 12, Pages: 1415-1420
Abstract
Successful embryo implantation depends on trophoblast proliferation migration and lastly invasion of the endometrium to anchor the trophoblast to the uterus This invasion is mediated by locally produced soluble factors Of these vascular endothelial growth factor VEGF is the best characterized regulator of angiogenesis Here we investigate the association between the VEGF + 405 C/G genotype and the recurrence of embryo implantation failure in women undergoing in vitro fertilization IVF program with intracytoplasmic sperm injection ICSIForty women with recurrent implantation failure defined by absence of pregnancy after transfer of more than 10 embryos and 131 women control with at least one live birth after the transfer of fewer than 10 embryos were included Genomic DNA was analysed with an allelespecific polymerase chain reaction and a Chi2 test was used to compare the respective VEGF + 405 C/G genotype frequencies in cases and controls
Keywords: