Authors: Patrizia Rubino Simone Palini Sara Chigioni Gianfranco Carlomagno Antonella Quagliariello Silvia De Stefani Andrea Baglioni Carlo Bulletti
Publish Date: 2015/01/20
Volume: 32, Issue: 3, Pages: 387-394
Abstract
This is a prospective bicentric randomized study on 500 MII sibling oocytes injected in 78 ICSI cycles performed between March and October 2013 Randomization of the oocytes into two groups was performed at the time of the denudation Fertilization rates per oocyte injected with spermatozoa treated with myoinositol versus per oocyte injected with spermatozoa treated with placebo were measured as primary outcome and embryo morphology as secondary outcome Clinical outcomes were also documentedFertilization rate 789 ± 286 vs 632 ± 367 P = 0002 and percentage of grade A embryos on day 3 598 ± 356 vs 435 ± 415 P = 0019 were significantly higher when spermatozoa were treated in vitro with myoinositol versus placebo No differences were found for the expanded blastocyst formation rateIn vitro treatment of spermatozoa with myoinositol may optimize ICSI outcomes by improving the fertilization rate and embryo quality on day 3 The improvement of the number and the quality of embryos available in an ICSI cycle may have clinical utility if these findings can be confirmedPR conceived the idea of the study and its design She was also responsible for the collection analysis and interpretation of data for writing the first version of this manuscript and for reviewing and approving the final version of the manuscript GC and SP contributed for the analysis and interpretation of the data and approved the final version of the manuscript SC AQ SDS were responsible for sperm preparation and data collection and for approving the final version of the manuscript CB supervised the study and approved the final version of the manuscript
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