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Title of Journal: J Assist Reprod Genet

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Abbravation: Journal of Assisted Reproduction and Genetics

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Springer US

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DOI

10.1002/chin.199416104

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1573-7330

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Improving fertilization rate in ICSI cycles by add

Authors: Patrizia Rubino Simone Palini Sara Chigioni Gianfranco Carlomagno Antonella Quagliariello Silvia De Stefani Andrea Baglioni Carlo Bulletti
Publish Date: 2015/01/20
Volume: 32, Issue: 3, Pages: 387-394
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Abstract

This is a prospective bicentric randomized study on 500 MII sibling oocytes injected in 78 ICSI cycles performed between March and October 2013 Randomization of the oocytes into two groups was performed at the time of the denudation Fertilization rates per oocyte injected with spermatozoa treated with myoinositol versus per oocyte injected with spermatozoa treated with placebo were measured as primary outcome and embryo morphology as secondary outcome Clinical outcomes were also documentedFertilization rate 789 ± 286  vs 632 ± 367 P = 0002 and percentage of grade A embryos on day 3 598 ± 356  vs 435 ± 415 P = 0019 were significantly higher when spermatozoa were treated in vitro with myoinositol versus placebo No differences were found for the expanded blastocyst formation rateIn vitro treatment of spermatozoa with myoinositol may optimize ICSI outcomes by improving the fertilization rate and embryo quality on day 3 The improvement of the number and the quality of embryos available in an ICSI cycle may have clinical utility if these findings can be confirmedPR conceived the idea of the study and its design She was also responsible for the collection analysis and interpretation of data for writing the first version of this manuscript and for reviewing and approving the final version of the manuscript GC and SP contributed for the analysis and interpretation of the data and approved the final version of the manuscript SC AQ SDS were responsible for sperm preparation and data collection and for approving the final version of the manuscript CB supervised the study and approved the final version of the manuscript


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  1. Time-lapse evaluation of human embryo development in single versus sequential culture media—a sibling oocyte study
  2. Clinical evaluation of two formulations of slow-freezing solutions for cleavage stage embryos
  3. Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential
  4. Dehydroepiandrosterone (DHEA) supplementation results in supraphysiologic DHEA-S serum levels and progesterone assay interference that may impact clinical management in IVF
  5. CYP2C19 polymorphism increases the risk of endometriosis
  6. CYP2C19 polymorphism increases the risk of endometriosis
  7. Nuclei size in relation to nuclear status and aneuploidy rate for 13 chromosomes in donated four cells embryos
  8. The use of parthenotegenetic and IVF bovine blastocysts as a model for the creation of human embryonic stem cells under defined conditions
  9. Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation
  10. Live birth following transfer of a cryopreserved embryo generated from a cryopreserved oocyte and a cryopreserved sperm: Case report
  11. Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes
  12. Chromosome distribution of early miscarriages with present or absent embryos: female predominance
  13. Derivation of human embryonic stem cell lines from single blastomeres of low-quality embryos by direct plating
  14. Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility
  15. Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective study
  16. IVF results in patients with very low serum AMH are significantly affected by chronological age
  17. Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland
  18. Abnormally low expression of connexin 37 and connexin 43 in subcutaneously transplanted cryopreserved mouse ovarian tissue
  19. Association of WNT4 polymorphisms with endometriosis in infertile patients
  20. Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?
  21. Sequential (hFSH + recFSH) vs homogenous (hFSH or recFSH alone) stimulation: clinical and biochemical (cumulus cell gene expression) aspects
  22. Correlation between follicular diameters and flushing versus no flushing on oocyte maturity, fertilization rate and embryo quality
  23. The role of epigenetics in idiopathic male infertility
  24. Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters
  25. Dicer is a key player in oocyte maturation
  26. The vascular endothelial growth factor ( VEGF ) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI
  27. Clinically applied procedures for human ovarian tissue cryopreservation result in different levels of efficacy and efficiency
  28. Comparison of differences in development potentials between frozen-thawed D5 and D6 blastocysts and their relationship with pregnancy outcomes
  29. Luteal phase GnRHa trigger in random start fertility preservation cycles
  30. Feasibility and results of a modified intrafollicular insemination technique for treating primary infertility
  31. Caspase-3 and VEGF immunopositivity in seminiferous tubule germ cells in cases of obstructive and non-obstructive azoospermia in smokers versus non-smokers
  32. Relative expression of genes encoding SMAD signal transduction factors in human granulosa cells is correlated with oocyte quality
  33. Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile 49 Ser) and Anti-Müllerian hormone type II receptor (AMHRII −482 A>G) as genetic markers in assisted reproduction technology
  34. Single thawed euploid embryo transfer improves IVF pregnancy, miscarriage, and multiple gestation outcomes and has similar implantation rates as egg donation
  35. Using the oocyte donation model to identify early trophoblast pregnenolone production
  36. Uterine vascularization and pregnancy outcome in patients undergoing intracytoplasmatic sperm injection: The role of nitric oxide
  37. Lack of carbon air filtration impacts early embryo development
  38. The importance of the cleavage stage morphology evaluation for blastocyst transfer in patients with good prognosis
  39. Matrix metalloproteinases in serum and the follicular fluid of women treated by in vitro fertilization
  40. Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway
  41. Predictors of treatment failure in young patients undergoing in vitro fertilization

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