Authors: J Barcroft N Dayoub K J Thong
Publish Date: 2013/07/09
Volume: 30, Issue: 11, Pages: 1407-1413
Abstract
Fortytwo oncology patients mean 319 ± 39 years underwent embryo cryopreservation treatment n = 33 IVF n = 6 ICSI Controlled ovarian stimulation with GnRH antagonist protocol n = 34 81 yielded fewer oocytes than GnRH agonist protocol n = 8 19 94 ± 63 vs 153 ± 89 p = 004 respectively There was no significant difference in mean ±SD duration of ovarian stimulation 116 ± 26 vs106 ± 27 median gonadotrophin dose 1950 vs 1670 IU median day 5–6 oestradiol level 1124 vs1129 pmol/l or embryo yield 62 ± 41 vs 88 ± 43 p = 007 between GnRH antagonist and agonist treatment cycles respectively Thirtynine patients cryopreserved embryos and three had their cycle cancelled During this study period of those who cryopreserved embryos 5 patients underwent 9 frozenthaw cycles 13 resulting in 2 live births 1 twin 1 singleton live birth rate 22 Six patients died 15 3 conceived naturally 8 and 2 couples separated 5 Fourteen patients discarded their embryos 36 Twentytwo patients’ 56 have embryos remaining in storageThis study demonstrates that embryo cryopreservation in female oncology patients gives a satisfactory live birth rate However there are concerns regarding costeffectiveness resulting from high disposal/nonusage of embryos and further studies are requiredJB contributed to the conception and design acquisition analysis and interpretation of data and drafted the article JT and ND contributed to conception and design acquisition of data and were involved in the critical revision of the intellectual content of the manuscript
Keywords: