Authors: Denis A Vaughan Conor Harrity E Scott Sills Edgar V Mocanu
Publish Date: 2016/02/06
Volume: 33, Issue: 4, Pages: 481-488
Abstract
This retrospective analysis included all IVF cycles where oocyte collection and fresh transfer occurred between January 2001 and November 2012 at a single institution Patients were divided by three age groups 35 35–39 and ≥40 years and further stratified into nine groups based on EOR measured in pmol/L/oocyte Terminal serum E2 pmol/mL was recorded on day of hCG trigger administration and fertilization rate cleavage rate number of good quality embryos and reproductive outcomes were recorded for each IVF cycleDuring the study interval 9109 oocyte retrievals were performed for 5499 IVF patients mean = 17 cycles/patient A total of 634 of transfers were performed on day 3 n = 4926 while 366 were carried out on day 5 n = 2843 Clinical pregnancy rates were highest in patients with EOR of 250–750 and declined as this ratio increased independent of patient age While the odds ratio OR for clinical pregnancy where EOR = 250–750 vs EOR 1500 was 34 p 0001 95 CI 267–434 no statistically significant correlation was seen in fertilization cleavage rates or number of good quality embryos as a function of EORPredicting reproductive outcomes with IVF has great utility both for patients and providers The former have the opportunity to build realistic expectations and the latter are better able to counsel according to measured clinical parameters A better understanding of follicular dynamics and ovarian response to gonadotropin stimulation could optimize IVF treatments going forwardDAV was the principal investigator He collected all data and was responsible for the study concept CH was the research associate and contributed to the statistical analysis ESS and EVM supervised the project and assisted with the manuscript development and revisions All authors read and approved the final version of the work
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