Authors: Enis Ozkaya Gabriel San Roman Kutluk Oktay
Publish Date: 2012/04/11
Volume: 29, Issue: 6, Pages: 503-505
Abstract
Depending on the type of cancer and how early the patient is referred before chemotherapy there may nor may not be sufficient time to wait for the menstrual period to initiate ovarian stimulation for embryo or oocyte freezing We have previously reported a “Random Start Controlled Ovarian Stimulation”RSCOH protocol where females with breast cancer were initiated on letrozole and gonadotropins followed by human chorionic gonadotropin hCG trigger regardless of where they were in their menstrual cycle even postovulation 5 This approach resulted in a considerable number of oocytes and embryos We have also reported previously that use of GnRHa trigger instead of hCG reduces ovarian hyperstimulation syndrome OHSS risks and estrogen exposure in letrozolegonadotropin cycles 4 OHSS may carry additional risks as cancer patients are already prone to thromboembolic events In addition development of severe OHSS as well as hCG triggerinduced false positive
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