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Title of Journal: J Assist Reprod Genet

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Abbravation: Journal of Assisted Reproduction and Genetics

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Springer US

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DOI

10.1016/0736-5748(85)90058-9

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ISSN

1573-7330

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Single nucleotide polymorphisms in the AntiMüller

Authors: Iro Karagiorga George A Partsinevelos Despina Mavrogianni Elli Anagnostou Ioannis Zervomanolakis Konstantinos Kallianidis Petros Drakakis Dimitris Loutradis
Publish Date: 2014/12/27
Volume: 32, Issue: 3, Pages: 357-367
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Abstract

The aim of the study was to evaluate whether the presence Antimullerian hormone AMH and Antimullerian hormone type II receptor AMHRII single nucleotide polymorphisms SNPs Ile49Ser and 482AG respectively are related to the assisted reproduction outcomeA prospective crosssectional observational study was conducted in order to assess the distribution of AMH and AMHRII SNPs in two cohorts one of healthy women N = 100 and the control group and the IVF/ICSI group N = 151 consisted of women undergoing IVF/ICSI treatment for infertility Furthermore a prospective longitudinal observational study was performed on the latter group to assess possible associations of these SNPs with patients’ characteristics and controlled ovarian stimulation COS and pregnancy outcomeAmong noncarriers of the AMH Ile49Ser polymorphism basal FSH levels were lower in those with more than two of previous IVF attempts and fertilization rate was statistically higher in those with peak serum E2 levels below 1500 pg/ml whereas among noncarriers of the AMHRII −482 AG polymorphism number of follicles was higher in those with more than two previous IVF attempts and total dose of gonadotropins was lower in those with peak serum E2 levels above 1500 pg/mlThere was evidence that in specific subgroups of women undergoing IVF/ICSI AMH and AMHRII SNPs may be related to patients’ characteristics and controlled ovarian stimulation and pregnancy outcome and thus may provide a means for the prediction of ovarian response in specific subgroups of women entering an IVF/ICSI programThis research was funded by Postgraduate Master Degree Program “Reproductive Regenerative Medicine” of National Kapodistrian University of Athens Medical School directed by Professor D Loutradis The authors have no potential conflict of interest to declare

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  14. Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility
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