Authors: Li Fang Liang Jin Enshu Li Long Cui Yinghui Ye
Publish Date: 2016/07/27
Volume: 33, Issue: 10, Pages: 1389-1393
Abstract
The evaluation was divided into two parts The first part was a retrospective analysis of results obtained after freezing and thawing of day 3 embryos from 400 women using an old formulation of cryopreservation solutions compared to results from 108 women for which cryopreservation had been performed using new compositions of solutions The second part was prospective adding cycles until similar numbers of patients had been included in both groups In total 2274 embryos from 897 patients were thawed using the old formulation of solutions while 1273 embryos from 542 patients were frozen and thawed using the new solutions The primary endpoint was survival rateWith the new solutions the survival rate increased from 821 to 944 and the complete embryo survival rate increased from 549 to 813 The implantation rate clinical pregnancy rate per embryo transfer and per cycle were 282 452 and 437 respectively using the old formulations of cryosolutions With the new solutions the results reached 337 541 and 541 respectively All differences in results were statistically significant The number of cancelled embryo transfers due to no survived embryos was 18 with the old solutions and 0 using the new solutionsAll procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards Informed consent was obtained from all individual participants included in the study
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