Authors: Hongyi Yang Qingling Yang Shanjun Dai Gang Li Haixia Jin Guidong Yao Yingpu Sun
Publish Date: 2016/04/21
Volume: 33, Issue: 7, Pages: 865-872
Abstract
Whether there are differences in the pregnancy outcomes of blastocysts cryopreserved during different developmental stages remains under debate because the results among studies are inconsistent We analyzed blastocyst quality and pregnancy outcomes by considering blastocyst euploidy and investigated the differences in the development potential between blastocysts of different developmental stages frozenthawed day 5 D5 and day 6 D6 cycles and their relationship with clinical pregnancy outcomesIn total 1374 D5 and 255 D6 frozenthawed blastocyst transfer cycles were retrospectively analyzed Additionally the chromosome euploidy and clinical pregnancy rates of 237 blastocysts from 50 preimplantation genetic diagnosis PGS cycles were statistically analyzed The corresponding euploidy rate and pregnancy outcomes of the D5 and D6 blastocyst transfers were also comparedThe clinical pregnancy rate 472 vs 400 P = 004 and implantation rate 342 vs 288 P = 003 of the D5 blastocysts were higher than were those of the D6 blastocysts However the clinical pregnancy rate 524 vs 526 P = 097 and implantation rate 389 vs 356 P = 039 of the highquality D5 blastocysts did not significantly differ from those of the highquality D6 blastocysts Analysis of blastocyst euploidy in 237 blastocysts examined in 50 PGS cycles showed that the euploidy rates of the D5 and D6 blastocysts were both 481 P = 099 The clinical pregnancy rate of the D5 blastocysts 485 vs 176 P = 003 was higher than that of the D6 blastocysts The euploidy rates 552 vs 553 P = 099 and clinical pregnancy rates 600 vs 429 P = 077 of the highquality D5 and D6 blastocysts did not differ The euploidy rate 553 vs 415 P = 003 and clinical pregnancy rate 545 vs 250 P = 003 of the highquality blastocysts were higher than were those of the poorquality blastocystsThe euploidy rates between the D5 and D6 blastocysts did not differ Highquality D6 blastocysts in frozenthawed cycles had similar developmental potential and pregnancy outcomes compared to those of highquality D5 blastocysts The quality of the blastocysts was an important factor that affected the pregnancy outcomes of the frozenthawed cycles
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