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Title of Journal: J Assist Reprod Genet

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Abbravation: Journal of Assisted Reproduction and Genetics

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Springer US

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DOI

10.1007/s11704-010-0077-4

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1573-7330

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Emphasis Type="Italic"CYP2C19/Emphasis polymor

Authors: Denise Maria Christofolini Aline Amaro Fernanda Mafra Amanda Sonnewend Bianca Bianco Caio Parente Barbosa
Publish Date: 2014/11/18
Volume: 32, Issue: 1, Pages: 91-94
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Abstract

Five hundred women with endometriosis and 500 women without endometriosis were tested for CYP2C19 and HSD17B1 polymorphisms by TaqMan Real Time PCR The results were statistically analyzed by chisquare logistic regression and tested for HardyWeinberg equilibriumThe comparison of genotype and allelic frequency of CYP2C19 polymorphism rs11592737 in patients with endometriosis and control group showed a statistically significant difference p = 00203 and for the HSD17B1 polymorphism rs605059 differences were not significant p = 00687 Comparing the stages I/II and III/IV endometriosis with the control group for the CYP2C19 we observed p = 00133 and p = 00564 respectively and for HSD17B1 the values for p = 04319 and p = 00667Capsule In a casecontrol study comprising 500 women with endometriosis and 500 women without the disease we were able to demonstrate a statistically difference considering genotype and allelic frequency of CYP2C19 polymorphism rs11592737 Comparing endometriosis cases classified as stages I/II and III/IV with control group for the CYP2C19 we observed that the polymorphism is more frequent in the cases with stages I/II Regarding HSD17B1 polymorphism no association was also found We concluded that CYP2C19 polymorphism is associated to endometriosis in Brazilian women and can be considered a potential biomarker of the disease

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