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Title of Journal: J Assist Reprod Genet

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Abbravation: Journal of Assisted Reproduction and Genetics

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Springer US

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DOI

10.1007/s00253-009-2053-1

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1573-7330

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The role of epigenetics in idiopathic male inferti

Authors: Sezgin Gunes Mehmet Alper Arslan Gulgez Neslihan Taskurt Hekim Ramazan Asci
Publish Date: 2016/03/03
Volume: 33, Issue: 5, Pages: 553-569
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Abstract

Infertility is a complex disorder with multiple genetic and environmental causes Although some specific mutations have been identified other factors responsible for sperm defects remain largely unknown Despite considerable efforts to identify the pathophysiology of the disease we cannot explain the underlying mechanisms of approximately half of infertility cases This study reviews current data on epigenetic regulation and idiopathic male infertility Recent data have shown an association between epigenetic modifications and idiopathic infertility In this regard epigenetics has emerged as one of the promising research areas in understanding male infertility Many studies have indicated that epigenetic modifications including DNA methylation in imprinted and developmental genes histone tail modifications and short noncoding RNAs in spermatozoa may have a role in idiopathic male infertility

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Other Papers In This Journal:
  1. Time-lapse evaluation of human embryo development in single versus sequential culture media—a sibling oocyte study
  2. Clinical evaluation of two formulations of slow-freezing solutions for cleavage stage embryos
  3. Apoptotic sperm biomarkers and their correlation with conventional sperm parameters and male fertility potential
  4. Dehydroepiandrosterone (DHEA) supplementation results in supraphysiologic DHEA-S serum levels and progesterone assay interference that may impact clinical management in IVF
  5. CYP2C19 polymorphism increases the risk of endometriosis
  6. CYP2C19 polymorphism increases the risk of endometriosis
  7. Nuclei size in relation to nuclear status and aneuploidy rate for 13 chromosomes in donated four cells embryos
  8. The use of parthenotegenetic and IVF bovine blastocysts as a model for the creation of human embryonic stem cells under defined conditions
  9. Fifteen year follow-up of embryos cryopreserved in cancer patients for fertility preservation
  10. Live birth following transfer of a cryopreserved embryo generated from a cryopreserved oocyte and a cryopreserved sperm: Case report
  11. Use of the natural cycle and vitrification thawed blastocyst transfer results in better in-vitro fertilization outcomes
  12. Chromosome distribution of early miscarriages with present or absent embryos: female predominance
  13. Derivation of human embryonic stem cell lines from single blastomeres of low-quality embryos by direct plating
  14. Evaluation of in vitro fertilization parameters and estrogen receptor alpha gene polymorphisms for women with unexplained infertility
  15. Effect of the size of zona pellucida opening by laser assisted hatching on clinical outcome of frozen cleaved embryos that were cultured to blastocyst after thawing in women with multiple implantation failures of embryo transfer: a retrospective study
  16. IVF results in patients with very low serum AMH are significantly affected by chronological age
  17. Serum estradiol:oocyte ratio as a predictor of reproductive outcome: an analysis of data from >9000 IVF cycles in the Republic of Ireland
  18. Abnormally low expression of connexin 37 and connexin 43 in subcutaneously transplanted cryopreserved mouse ovarian tissue
  19. Association of WNT4 polymorphisms with endometriosis in infertile patients
  20. Day 3 ET, single blastocyst transfer (SBT) or frozen-thawed embryo transfer (FET): which is preferable for high responder patients in IVF/ICSI cycles?
  21. Sequential (hFSH + recFSH) vs homogenous (hFSH or recFSH alone) stimulation: clinical and biochemical (cumulus cell gene expression) aspects
  22. Correlation between follicular diameters and flushing versus no flushing on oocyte maturity, fertilization rate and embryo quality
  23. Deliveries of babies with normal health derived from oocytes with smooth endoplasmic reticulum clusters
  24. Dicer is a key player in oocyte maturation
  25. The vascular endothelial growth factor ( VEGF ) +405 G/C polymorphism and its relationship with recurrent implantation failure in women in an IVF programme with ICSI
  26. Clinically applied procedures for human ovarian tissue cryopreservation result in different levels of efficacy and efficiency
  27. Comparison of differences in development potentials between frozen-thawed D5 and D6 blastocysts and their relationship with pregnancy outcomes
  28. Luteal phase GnRHa trigger in random start fertility preservation cycles
  29. Feasibility and results of a modified intrafollicular insemination technique for treating primary infertility
  30. Caspase-3 and VEGF immunopositivity in seminiferous tubule germ cells in cases of obstructive and non-obstructive azoospermia in smokers versus non-smokers
  31. Relative expression of genes encoding SMAD signal transduction factors in human granulosa cells is correlated with oocyte quality
  32. Single nucleotide polymorphisms in the Anti-Müllerian hormone (AMH Ile 49 Ser) and Anti-Müllerian hormone type II receptor (AMHRII −482 A>G) as genetic markers in assisted reproduction technology
  33. Single thawed euploid embryo transfer improves IVF pregnancy, miscarriage, and multiple gestation outcomes and has similar implantation rates as egg donation
  34. Using the oocyte donation model to identify early trophoblast pregnenolone production
  35. Uterine vascularization and pregnancy outcome in patients undergoing intracytoplasmatic sperm injection: The role of nitric oxide
  36. Lack of carbon air filtration impacts early embryo development
  37. The importance of the cleavage stage morphology evaluation for blastocyst transfer in patients with good prognosis
  38. Improving fertilization rate in ICSI cycles by adding myoinositol to the semen preparation procedures: a prospective, bicentric, randomized trial on sibling oocytes
  39. Matrix metalloproteinases in serum and the follicular fluid of women treated by in vitro fertilization
  40. Bu Shen Tiao Chong recipe restores diminished ovary reserve through the BDNF pathway
  41. Predictors of treatment failure in young patients undergoing in vitro fertilization
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