Authors: Xiaoxia Zhu Lijuan Hou Jian Zhang Cijiang Yao Ying Liu Chao Zhang Yachun Xu Jiyu Cao
Publish Date: 2016/05/13
Volume: 23, Issue: 16, Pages: 16567-16578
Abstract
A growing body of epidemiological evidence has supported the association between maternal exposure to airborne fine particulate matter PM25 during pregnancy and adverse pregnancy outcomes However the specific biological mechanisms implicated in the causes of adverse pregnancy outcomes are not well defined In this study a pregnant rat model of exposure to different doses of cooking oil fumes COFsderived PM25 by tail intravenous injection in different pregnant stages was established The results indicated that exposure to COFsderived PM25 was associated with adverse pregnancy outcomes changed the structure of umbilical cord blood vessels decreased the diameter and lumen area and increased wall thickness What’s more a significant increase of maximum contraction tension was observed in the early pregnancy highdose exposure group and pregnant lowdose exposure group compared to the control group Based on the maximum contraction tension acetylcholine ACh did not induce vasodilation but caused a dosedependent constriction and there were significant differences in the two groups compared to the control group Exposure to COFsderived PM25 impaired the vasomotor function of umbilical veins by affecting the expression of NO and ET1 This is the first study that evaluated the association of risk of adverse pregnancy outcomes and pregnant rats exposed to COFsderived PM25 and primarily explored the potential mechanisms of umbilical cord blood vessels injury on a rat model More detailed vitro and vivo studies are needed to further explore the mechanism in the future
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