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Title of Journal: Z Ernährungswiss

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Abbravation: Zeitschrift für Ernährungswissenschaft

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Steinkopff-Verlag

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DOI

10.1002/ep.670190115

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1435-1293

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Role of vitamin D metabolites in the prevention of

Authors: R G Erben B Kohn H Weiser F Sinowatz W A Rambeck
Publish Date: 1990/12/01
Volume: 29, Issue: 4, Pages: 229-248
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Abstract

Forty Fischer344 rats 10 weeks old 130 g BW were either bilaterally ovariectomized OVX or shamoperated SHAM The rats were allocated to the following groups SHAM OVX OVX + 15 ng 1α25dihydroxyvitamin D3 125OH2D3/rat/d OVX + 30 ng 1α24R25trihydroxyvitamin D3 12425OH3D3/ rat/d OVX + 15 ng 125OH2D3/rat/d + 30 ng 12425OH3D3/rat/d The vitamin D metabolites were fed orally starting 4 weeks after surgery Urine and blood samples were taken at several time points during the experiment Twentyone weeks after surgery all rats were sacrificed and the proximal tibiae and the first lumbar vertebrae were processed undecalcified for static bone histomorphometryOvariectomy induced a 40 reduction in vertebral cancellous bone area and a 69 reduction in tibial cancellous bone area This bone loss in OVX rats was associated with moderately increased biochemical and histomorphometric indices of bone formation and resorption as compared to values in shamoperated animals Through inhibition of bone resorption treatment of OVX rats with 125OH2D3 12425OH3D3 and the metabolite combination prevented the ovariectomyinduced osteopenia in the lumbar vertebra and partially prevented cancellous bone osteopenia in the tibial metaphysis However OVX rats receiving 125OH2D3 alone or in combination with 12425OH3D3 exhibited hypercalcemia hyperphosphatemia hypercalciuria and impaired bone mineralization Treatment of OVX rats with 12425OH3D3 alone on the other hand only slightly increased serum calcium levels and did not impair bone mineralization Furthermore the inclusion of 12425OH3D3 with 125OH2D3 partially antagonized the untoward effects of 125OH2D3 on bone mineralizationThese data suggest that the actions of 12425OH3D3 on bone metabolism might differ from that of 125OH2D3 and that 125OH2D3 and particularly 12425OH3D3 may be potentially effective agents for the prophylaxis of postmenopausal osteoporosis

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