Authors: de Dombal F T Softley A
Publish Date: 1995/11/01
Volume: 1, Issue: 4, Pages: 247-255
Abstract
F T de Dombal A Softley Observations on Severity and Activity Indices in a Therapeutic Trial of Active Crohns Disease Inflammatory Bowel Diseases Volume 1 Issue 4 1 November 1995 Pages 247–255 https//doiorg/101097/0005472519951200000002We describe the use of activity indices during a prospective trial of 91 patients with active Crohns disease Data were recorded by experienced physician investigators in four centres and several activity indices were compared The indices studied included modifications of the Crohns Disease Activity Index CDAI the Dutch Activity Index and the European Severity/Activity Index Correlation was made between each index between the indices and physicians opinion and between each index and patient progress The correlation between indices was generally somewhat higher than that observed during a similar study in the early 1980s Our results suggest close correlation between the variants of the CDAI but less good correlation with the Dutch or European indices There was also good correlation between CDAI variants and physicians opinion both as measured on linear analogue scale and as measured by physician action All assessed indices correlated poorly however with shortterm patient prognosis New indices or combinations of existing datasets will be necessary to solve this problem
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