Authors: Doherty Glen A Cheifetz Adam S
Publish Date: 2009/12/01
Volume: 15, Issue: 12, Pages: 1925-1926
Abstract
Glen A Doherty Adam S Cheifetz Targeting TNF in Postoperative Recurrence of Crohns DiseaseCan We Extinguish the Fire Before It Starts Inflammatory Bowel Diseases Volume 15 Issue 12 1 December 2009 Pages 1925–1926 https//doiorg/101002/ibd20973Most patients with Crohns disease CD require an intestinal resection Unfortunately surgery is not curative and the majority of patients develop recurrent disease To date studies evaluating medications for the prevention of postoperative CD have been inconsistent and disappointing Regueiro et al set out to investigate the effect of infliximab on the postoperative recurrence of CD after intestinal resection and ileocolic anastomosis The study was a singlecenter randomized doubleblind placebocontrolled trial examining the efficacy of infliximab in the prevention of endoscopic histologic and clinical recurrence of CD after intestinal resection Twentyfour patients with ileal or ileocolonic CD who had undergone resection were randomly assigned to receive infliximab 5 mg/kg n = 11 or placebo n = 13 starting within
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